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KMID : 0604219940010010021
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Korean Journal Investigative Dermatology
1994 Volume.1 No. 1 p.21 ~ p.26
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Reactive Oxygen Intermediates-Generating Activities by Peripheral
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전봉길/Jeon BK
박석돈/Park SD
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Abstract
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Superoxide anion and hydrogen peroxide are reactive oxygen intermediates (ROI) primarily produced by phagocytic cells as a consequence of phagocytosis. ROI is known to be an important effector molecule for bactericidal and tumoricidal activities.
It is generally believed that the patients with chronic liver diseases have increased susceptibility to infection. Vibrio vulnificus septicemia frequently develops in the patients with hepatic cirrhosis. The purpose of this study is to evaluate the ROI-generating activity of PMN from patients with hepatic cirrhosis. Production of ROI by PMN was studied in 20 patients with liver cirrhosis and in 15 healthy controls. The activity of ROI was measured by luminometer. Superoxide anion and hydrogen peroxide production were highly increased in the patients with liver cirrhosis compared to the healthy control, 230±123% and 274±150% (P<0.05), respectively.
These results suggest that PMN of the patients with hepatic cirrhosis are always in a state of oxidative priming, and induce overproduction of ROI to exogenous stimuli. Therefore, increased susceptibility to sepsis in cirrhotic patients may be associated with other factors besides oxygendependent antimicrobial activity.
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KEYWORD
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